Sodium Hydroxide → HCID 67090018, compound

Participants

Reaction Steps

Stir and heat at 70° C. a solution of 4-chloro-N-{3-[4-(1-formylaminomethyl-5-methoxy-6-methyl-isochroman-3-yl)-piperidin-1-yl]-1-methylpropyl}-benzamide in CH3OH/THF (10 mL of 1:1 solution) and of 15% NaOH solution (2 mL) for 4 hours. Concentrate the reaction mixture, and extract three times with EtOAc (2 mL). Wash the combined organic phase sequentially with H2O (2 mL), brine (2 mL), and then dry over MgSO4. Concentrate and purify the crude product on a 2 g SCX column.

Provenance & Evidence