Aluminum(III) Chloride → HCID 67090221, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 0.5M LiAlH4 in THF (3 mL) at 8° C., add of AlCl3 (35 mg) and (1R,3S)-N-[5-Isopropoxy-6-methyl-3-(1-phenethyl-piperidin-4-yl)-isochroman-1-ylmethyl]-formamide in THF (2 mL). Allow the reaction mixture to warm to 20° C. and stir for 4 hours. Cool to 8° C. and quench by slow addition of saturated, aqueous. NH4Cl to pH 8. Add EtOAc (8 mL) and then filter the mixture separate the organic layer and concentrate. Purify the residue by chromatography on a 1 g silica gel column (eluent: 10% CH3OH/CH2Cl2). Collect the appropriate fractions and concentrate to obtain the title compound.

Provenance & Evidence