Carbon Dioxide → HCID 23070103, compound

HRID 2074475Notes

Reaction equation

HRID 2074475 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[F:11])[NH:7][N:6]=[CH:5]2.C([Li])(C)(C)C.[C:17](=[O:19])=[O:18]>>[F:11][C:10]1[CH:9]=[C:8]2[C:4]([CH:5]=[N:6][NH:7]2)=[CH:3][C:2]=1[C:17]([OH:19])=[O:18]

Participants

4

Reactant 3

HCID 280Carbon DioxideHCID 468639235-Bromo-6-fluoro-1H-indazoleHCID 178418306HCID 178418306, compound

Product 1

HCID 23070103HCID 23070103, compound

Procedure

This compound was prepared in a manner similar to that shown in Scheme 3, using 5-bromo-6-fluoro-1H-indazole (88d), which was treated with t-butyl lithium and carbon dioxide to yield 6-fluoro-1H-indazole-5-carboxylic acid. This compound in turn was treated with thiosemicarbazide and polyphosphoric acid to form 5-(6-fluoro-1H-indazol-5-yl)-1,3,4-thiadiazol-2-amine. MS (API-ES) m/z (%): 236 (100%, M++1).

Workup

  1. customThis compound was prepared in a manner similar to

Sources & evidence

ORD record
ord-f61445372e3743eeaa7b81ae9b4193c0
Source dataset
uspto-grants-2011_04
Patent number
US07919514B2

Reaction notes

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