Sodium borohydride → HCID 57556190, compound

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Reaction Steps

Prepared according to Procedure B using 2-(2-fluorophenyl)-8-methylquinoline-3-carbaldehyde (0.725 g, 2.73 mmol), and sodium borohydride (0.155 g, 4.1 mmol, 1.5 eq) in THF (15 mL). (2-(2-fluorophenyl)-8-methylquinolin-3-yl)methanol was obtained as a yellow solid. 1H NMR (500 MHz, DMSO-d6) δ ppm 8.46 (1 H, s), 7.90 (1 H, d, J=7.9 Hz), 7.63 (1 H, d, J=6.7 Hz), 7.50-7.60 (3 H, m), 7.38 (1 H, d, J=7.9 Hz), 7.35-7.37 (1 H, m), 5.42 (1 H, t, J=5.5 Hz), 4.50 (2 H, d, J=5.5 Hz), 2.69 (3 H, s) Mass Spectrum (ESI) m/e=268.1 (M+1)

Provenance & Evidence