Thionyl Chloride → HCID 57556185, compound

Participants

Reaction Steps

Prepared according to Procedure C using (2-(2-fluorophenyl)-8-methylquinolin-3-yl)methanol (0.700 g, 2.62 mmol) in SOCl2 (2 mL, 27.4 mmol, 10.5 eq). 3-(chloromethyl)-2-(2-fluorophenyl)-8-methyl-quinoline (0.665 g, 89%) was obtained after purification as a brown foam. 1H NMR (500 MHz, DMSO-d6) δ ppm 8.61 (1 H, s), 7.92 (1 H, d, J=7.9 Hz), 7.71 (1 H, d, J=6.7 Hz), 7.53-7.66 (3H, m), 7.40 (2 H, t, J=7.9 Hz), 4.81 (2 H, s), 2.69 (3 H, s) Mass Spectrum (ESI) m/e=286.1 and 288.1 (M+1)

Provenance & Evidence