HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Bromomethyl)-1,4-difluorobenzene → 1-(2,5-Difluorobenzyl)-7-iodo-3,3-dimethyl-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Bromomethyl)-1,4-difluorobenzene | HCID 522830 | — |
| Reactant | 7-iodo-3,3-dimethyl-1H,2H,3H,4H-pyrido[2,3-b]pyrazin-2-one | HCID 57886040 | — |
| Product | 1-(2,5-Difluorobenzyl)-7-iodo-3,3-dimethyl-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-one | HCID 57885805 | 98% |
Reaction Steps
7-Iodo-3,3-dimethyl-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-one (237 mg) was reacted with 2,5-difluorobenzyl bromide as in General Procedure 1 to give the title compound as a white solid (98% yield). M.p. 198-201° C., LCMS: m/z=430.00 (M+H+), 1H-NMR (DMSO-d6, 400 MHz) δ 1.36 (s, 6H), 5.12 (s, 2H), 6.79-6.83 (m, 1H), 7.15-7.22 (m, 1H), 7.28-7.32 (m, 1H), 7.31 (s, 1H), 7.40 (s, 1H), 7.90 (s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07919502B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-1c93e387d7b54f9d813693874f2a00e0 |
| Source note | uspto-grants-2011_04 |