3-(piperazin-1-yl)-3,4-dihydroquinolin-2(1H)-one → 9-benzyl-7-[2-oxo-2-[4-(2-oxo-3,4-dihydro-1H-quinolin-3-yl)piperazin-1-yl]ethyl]-3,6,7,10-tetrahydropyrazolo[5,4-i][2]benzazepin-8-one

HRID 207465Notes

Reaction equation

HRID 207465 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][c:10]2[c:11]3[cH:12][n:13][nH:14][c:15]3[cH:16][cH:17][c:18]2[CH2:19][CH:20]([CH2:23][C:24](=[O:25])[OH:26])[C:21]1=[O:22].[Cl:44][c:45]1[c:46]2[nH:47][n:48][cH:49][c:50]2[c:51]2[c:83]([cH:84]1)[CH2:82][CH:61]([CH2:62][C:63](=[O:64])[N:65]1[CH2:66][CH2:67][CH:68]([N:69]3[CH2:70][c:71]4[c:72]([cH:73][cH:74][cH:75][cH:76]4)[NH:77][C:78]3=[O:79])[CH2:80][CH2:81]1)[C:59](=[O:60])[N:53]([CH2:54][C:55]([CH3:56])([CH3:57])[CH3:58])[CH2:52]2.[N:27]1([CH:33]2[C:34](=[O:43])[NH:35][c:36]3[cH:37][cH:38][cH:39][cH:40][c:41]3[CH2:42]2)[CH2:28][CH2:29][NH:30][CH2:31][CH2:32]1>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][c:10]2[c:11]3[cH:12][n:13][nH:14][c:15]3[cH:16][cH:17][c:18]2[CH2:19][CH:20]([CH2:23][C:24](=[O:26])[N:30]2[CH2:29][CH2:28][N:27]([CH:33]3[C:34](=[O:43])[NH:35][c:36]4[cH:37][cH:38][cH:39][cH:40][c:41]4[CH2:42]3)[CH2:32][CH2:31]2)[C:21]1=[O:22]

Participants

4

Reactant 3

HCID 597319433-(piperazin-1-yl)-3,4-dihydroquinolin-2(1H)-oneHCID 688264784-Chloro-9-(2,2-dimethylpropyl)-7-[2-oxo-2-[4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidin-1-yl]ethyl]-3,6,7,10-tetrahydropyrazolo[3,4-i][2]benzazepin-8-oneHCID 688289742-(9-Benzyl-8-oxo-3,6,7,10-tetrahydropyrazolo[5,4-i][2]benzazepin-7-yl)acetic acid

Product 1

HCID 1785171179-benzyl-7-[2-oxo-2-[4-(2-oxo-3,4-dihydro-1H-quinolin-3-yl)piperazin-1-yl]ethyl]-3,6,7,10-tetrahydropyrazolo[5,4-i][2]benzazepin-8-one

Sources & evidence

ORD record
ord-b24c51b445d94efb8959600e71ca22eb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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