HRID2074790

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2734639

1-Piperazinylpyrazine

C8H12N4

结构：O=C(O)c1ccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)cc1

HCID46906718

4-{1-[5-Chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}benzoic acid

C22H17ClF3N3O2

PRODUCTS

生成物

结构：O=C(c1ccc(-c2cnc3c(c2)N(Cc2cc(Cl)ccc2C(F)(F)F)CCN3)cc1)N1CCN(c2cnccn2)CC1

HCID58327799

未命名化合物

PROCEDURE

实验过程

4-{1-[5-chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl}benzoic acid was reacted with 2-(1-piperazinyl)pyrazine as in General Procedure 10 to give the title compound. LCMS: m/z=593.98 (M+H+); retention time=0.79 minutes.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2f75c3b6608b423a83c128f3ee5b23cf
来源数据集: uspto-grants-2011_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07919502B2
来源说明: uspto-grants-2011_04

反应 SMILES

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:28]([F:31])([F:30])[F:29])=[C:6]([CH:27]=1)[CH2:7][N:8]1[CH2:13][CH2:12][NH:11][C:10]2[N:14]=[CH:15][C:16]([C:18]3[CH:26]=[CH:25][C:21]([C:22]([OH:24])=O)=[CH:20][CH:19]=3)=[CH:17][C:9]1=2.[N:32]1([C:38]2[CH:43]=[N:42][CH:41]=[CH:40][N:39]=2)[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:28]([F:30])([F:31])[F:29])=[C:6]([CH:27]=1)[CH2:7][N:8]1[CH2:13][CH2:12][NH:11][C:10]2[N:14]=[CH:15][C:16]([C:18]3[CH:26]=[CH:25][C:21]([C:22]([N:35]4[CH2:36][CH2:37][N:32]([C:38]5[CH:43]=[N:42][CH:41]=[CH:40][N:39]=5)[CH2:33][CH2:34]4)=[O:24])=[CH:20][CH:19]=3)=[CH:17][C:9]1=2