참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | (S)-tert-Butyl 2-((2-chloroacetamido)methyl)pyrrolidine-1-carboxylate | HCID 59215816 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (S)-Hexahydropyrrolo[1,2-a]pyrazin-3(4H)-one | HCID 59215765 | — |
반응 단계
1,1-Dimethylethyl (2S)-2-{[(chloroacetyl)amino]methyl}-1-pyrrolidinecarboxylate (D11; 1.24, 4.5 mmol), was dissolved in 20 ml of DCM and treated with TFA (5 ml) at room temperature. After 1 h complete conversion into the desired material was observed and the reaction mixture was loaded onto a SCX cartridge. The product obtained after elution with 2M NH3 in MeOH was then dissolved in acetonitrile (30 ml) and treated with sodium carbonate (1.43 g, 10.34 mmol). The reaction mixture was heated at 60° C. for 6 hours; the crude obtained after removal is purified by flash-chromatography eluting with dichloromethane/MeOH 95/5 affording 310 mg.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07919491B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_04 |
|---|
| ORD ID | ord-54f7f3d8647d4d40a83f75f36851d7bc |
|---|
| 출처 메모 | uspto-grants-2011_04 |
|---|
