HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → (7S,9AS)-7-(((tert-butyldimethylsilyl)oxy)methyl)octahydropyrazino[2,1-c][1,4]oxazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Reactant | ((7S,9aS)-Octahydropyrazino[2,1-c][1,4]oxazin-7-yl)methanol | HCID 59215831 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (7S,9AS)-7-(((tert-butyldimethylsilyl)oxy)methyl)octahydropyrazino[2,1-c][1,4]oxazine | HCID 59215768 | — |
Reaction Steps
(7S,9aS)-octahydropyrazino[2,1-c][1,4]oxazin-7-ylmethanol (D50, 680 mg, 3.95 mmol) was almost dissolved in dry DCM (12 mL) before adding Et3N (1.10 mL, 7.90 mmol), followed by TBDMS-Chloride (894 mg, 5.93 mmol). The resulting reaction mixture was stirred over the weekend at R.T., under argon. Left stirring for 2 more hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07919491B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-29d9d83589124690b3c4e91662b809c3 |
| Source note | uspto-grants-2011_04 |