Borane;tetrahydrofuran → (3R)-3-methyloctahydro-2H-pyrazino[1,2-a]pyrazine

Participants

Reaction Steps

To a flask containing (3R)-3-methyltetrahydro-2H-pyrazino[1,2-a]pyrazine-1,4(3H,6H)-dione (D98, 353 mg, 1.927 mmol) was added 1M BH3-THF solution (20 mL) and it was heated to reflux for 20 h. MS analysis: m/z=156 (M+1 of the target product). To the reaction were added at 0° C. 10 mL of 6M HCl and it was heated to 90° C. for 20 h. The reaction mixture was purified by SCX, obtaining 243 mg of the target compound.

Provenance & Evidence