HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 16063766, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (8aR)-Octahydropyrrolo(1,2-a)pyrazine | HCID 7004239 | — |
| Reactant | 2-(3,5-Bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyrid-3-yl)-N,2-dimethylpropanamide | HCID 23502784 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 16063766 | HCID 16063766 | 44.7% |
Reaction Conditions
| Temperature | 150 °C |
|---|
Reaction Steps
The title compound was prepared starting from 100 mg (0.187 mmole) of 2-[3,5-bis(trifluoromethyl)phenyl]-N-[6-chloro-4-(4-fluoro-2-methylphenyl)-3-pyridinyl]-N,2-dimethylpropanamide (WO 2005/002577), 70 mg (0.554 mmol) of (8aR)-octahydropyrrolo[1,2-a]pyrazine, 52.2 mg of potassium carbonate (0.377 mmol); the reagents were dissolved in 0.6 ml of DMSO and the reaction mixture was heated at 150° C. overnight. Obtained after flash chromatography 52 mg of the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07919491B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-aa4bd419dce64412bee6edf66dd7b79e |
| Source note | uspto-grants-2011_04 |