HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 86642509, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 59215784 | HCID 59215784 | — |
| Reactant | HCID 86642510 | HCID 86642510 | — |
| Product | HCID 86642509 | HCID 86642509 | — |
Reaction Steps
2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[(3S,8aR)-3-(hydroxymethyl)hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-3-pyridinyl}-N,2-dimethyl propanamide (E81, 25 mg, 0.038 mmol) was converted to its hydrochloride as reported above in the procedure for 2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[(3R,8aR)-3-(hydroxymethyl)hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-3-pyridinyl}-N,2-dimethylpropanamide Hydrochloride (E80). Obtained 26 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07919491B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-b4e255a2acb44347b36c07baecd592c5 |
| Source note | uspto-grants-2011_04 |