HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 2-Hydrazinyl-4-methylpyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 2-Chloro-4-methylpyrimidine | HCID 11629607 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Hydrazinyl-4-methylpyrimidine | HCID 12389067 | 75.8% |
Reaction Steps
To a solution of 2-chloro-4-methylpyrimidine (6.06 g, 47.1 mmol) in MeOH (40 mL) was added hydrazine monohydrate (10 mL, 206 mmol). The solution was stirred for 16 h at room temperature and then purified by reverse phase HPLC to provide 4.43 g of the title compound. (76%) as a white solid. MH+125.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07919528B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-2654da8d86f94b4ab31a39d7ed3b21f5 |
| Source note | uspto-grants-2011_04 |