HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phthalic Anhydride → N-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)(tert-butoxy)formamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phthalic Anhydride | HCID 6811 | — |
| Reactant | tert-Butyl carbazate | HCID 70091 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | N-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)(tert-butoxy)formamide | HCID 801162 | 80.2% |
Reaction Steps
To a mixture of tert-butyl carbazate (5.15 g, 38.97 mmol) and phthalic anhydride (5.77 g, 38.97 mmol) was added CHCl3 (70 mL). The reaction mixture was refluxed for 18 h. Removal of the solvent under reduced pressure yielded 8.20 g (80%) of the title compound as a white solid. MH+263.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07919528B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-5ed06ebc1853489994b1ae9fa06ed262 |
| Source note | uspto-grants-2011_04 |