1,8-Diazabicyclo(5.4.0)undec-7-ene → 3-Azidomethyl-5-trifluoromethyl-benzonitrile

関与物質

反応条件

反応手順

A solution of 3-hydroxymethyl-5-trifluoromethyl-benzonitrile (200 mg, 0.994 mmol) in toluene (1 ml) at 0° C. was treated with diphenyl phosphoryl azide (328 mg, 1.19 mmol), followed by DBU (182 mg, 1.19 mmol) and stirred at 0° C. for 2 hours. The ice bath was removed and the reaction was stirred at room temperature for overnight. Reaction was diluted with ethyl acetate and washed with 10% HCl solution, dried over anhydrous magnesium sulphate and concentrated in vacuo. The residue was purified by silica gel chromatography over 12+S Biotage silica column (eluted with 0-30% ethyl acetate in hexanes) to yield the title compound (150 mg, 67%) as a colorless oil. 1H NMR (400 MHz, CDCl3) δ ppm 4.54 (s, 2H) 7.82 (s, 2H) 7.88 (s, 1H).

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