HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → N-(2-(1-methoxy-2,2-dimethylpropyl)-5-(trifluoromethyl)benzyl)-N-(3,5-bis(trifluoromethyl)benzyl)-2-methyl-2H-tetrazol-5-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | 2-{[(3,5-bis-trifluoromethyl-benzyl)(2-methyl-2H-tetrazol-5-yl)amino]-methyl}-4-trifluoromethyl-benzaldehyde | HCID 58966524 | — |
| Reactant | (3,5-Bis-trifluoromethyl-benzyl)-[2-(cyclobutyl-ethoxy-methyl)-5-trifluoromethyl-benzyl]-(2-methyl-2H-tetrazol-5-yl)-amine | HCID 58968657 | — |
| Reactant | HCID 178418310 | HCID 178418310 | — |
| Product | N-(2-(1-methoxy-2,2-dimethylpropyl)-5-(trifluoromethyl)benzyl)-N-(3,5-bis(trifluoromethyl)benzyl)-2-methyl-2H-tetrazol-5-amine | HCID 58968668 | — |
Reaction Steps
The title compound was prepared in an analogous manner to that described for the preparation of (3,5-bis-trifluoromethyl-benzyl)-[2-(cyclobutyl-ethoxy-methyl)-5-trifluoromethyl-benzyl]-(2-methyl-2H-tetrazol-5-yl)amine from 2-{[(3,5-bis-trifluoromethyl-benzyl)-(2-methyl-2H-tetrazol-5-yl)-amino]-methyl}-4-trifluoromethyl-benzaldehyde by the addition of tert-butylmagnesium chloride followed by O-methylation with methyl iodide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07919506B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-cc88d080d3f249e6a71bbf7191ad840e |
| Source note | uspto-grants-2011_04 |