HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(4-Methylbenzyl)-benzofuran-2-ylboronic acid → Methyl 1-(3-fluoro-4-(5-(4-methylbenzyl)benzofuran-2-yl)benzyl)azetidine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(4-Methylbenzyl)-benzofuran-2-ylboronic acid | HCID 58415297 | — |
| Reactant | Methyl 1-(4-bromo-3-fluorobenzyl)azetidine-3-carboxylate | HCID 59651823 | — |
| Product | Methyl 1-(3-fluoro-4-(5-(4-methylbenzyl)benzofuran-2-yl)benzyl)azetidine-3-carboxylate | HCID 58415298 | — |
Reaction Steps
In a similar manner as described in general procedure D, 5-(4-methylbenzyl)-benzofuran-2-ylboronic acid (150 mg, 0.56 mmol) was reacted with methyl 1-(4-bromo-3-fluorobenzyl)azetidine-3-carboxylate (155 mg, 0.51 mmol) to give methyl 1-(3-fluoro-4-(5-(4-methylbenzyl)benzofuran-2-yl)benzyl)azetidine-3-carboxylate as white solid: MS (ESI) m/z: Calculated: 443.51; Observed: 444.0 (M++1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07919519B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-f450265027c3485c92f5098649d6d355 |
| Source note | uspto-grants-2011_04 |