HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 1-(4-bromo-3-fluorobenzyl)azetidine-3-carboxylate → Ethyl 1-((4-(6-benzylbenzofuran-2-yl)-3-fluorophenyl)methyl)azetidine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 1-(4-bromo-3-fluorobenzyl)azetidine-3-carboxylate | HCID 58415312 | — |
| Reactant | 6-Benzylbenzofuran-2-ylboronic acid | HCID 58415403 | — |
| Product | Ethyl 1-((4-(6-benzylbenzofuran-2-yl)-3-fluorophenyl)methyl)azetidine-3-carboxylate | HCID 59651815 | — |
Reaction Steps
Synthesized according to Scheme B2 and general procedure F using ethyl 1-(4-bromo-3-fluorobenzyl)azetidine-3-carboxylate (0.150 g, 0.474 mmol) and 6-benzylbenzofuran-2-ylboronic acid (0.155 g, 0.617 mmol) to give ethyl 1-((4-(6-benzylbenzofuran-2-yl)-3-fluorophenyl)methyl)azetidine-3-carboxylate. MS (ESI) m/z: Calculated: 443.2; Observed: 444.1 (M++1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07919519B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-fa971ed7244d46bb82adae5c78321d54 |
| Source note | uspto-grants-2011_04 |