HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(1-Phenylpropyl)-benzofuran-2-ylboronic acid → Methyl 1-((3-fluoro-4-(5-(1-phenylpropyl)benzofuran-2-yl)phenyl)methyl)azetidine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(1-Phenylpropyl)-benzofuran-2-ylboronic acid | HCID 58415375 | — |
| Reactant | Methyl 1-(4-bromo-3-fluorobenzyl)azetidine-3-carboxylate | HCID 59651823 | — |
| Product | Methyl 1-((3-fluoro-4-(5-(1-phenylpropyl)benzofuran-2-yl)phenyl)methyl)azetidine-3-carboxylate | HCID 58415326 | — |
Reaction Steps
Synthesized according to Scheme B2 and general procedure F using methyl 1-(4-bromo-3-fluorobenzyl)azetidine-3-carboxylate (1.76 g, 5.81 mmol) and 5-(1-phenylpropyl)-benzofuran-2-ylboronic acid (1.63 g, 5.81 mmol) to give methyl 1-((3-fluoro-4-(5-(1-phenylpropyl)benzofuran-2-yl)phenyl)methyl)azetidine-3-carboxylate. MS (ESI) m/z: Calculated: 457.2; Observed: 458.3 (M++1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07919519B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-f106190c4040454b9b3541af1cfb59bf |
| Source note | uspto-grants-2011_04 |