HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 1-(4-bromo-3-fluorobenzyl)azetidine-3-carboxylate → Ethyl 1-(3-fluoro-4-(5-(2-phenylpropan-2-yl)benzofuran-2-yl)benzyl)azetidine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 1-(4-bromo-3-fluorobenzyl)azetidine-3-carboxylate | HCID 58415312 | — |
| Reactant | 5-(2-Phenylpropan-2-yl)benzofuran-2-ylboronic acid | HCID 58415400 | — |
| Product | Ethyl 1-(3-fluoro-4-(5-(2-phenylpropan-2-yl)benzofuran-2-yl)benzyl)azetidine-3-carboxylate | HCID 58415256 | — |
Reaction Steps
Synthesized according to Scheme B2, Step 2 and general procedure F from 5-(2-phenylpropan-2-yl)benzofuran-2-ylboronic acid and ethyl 1-(4-bromo-3-fluorobenzyl)azetidine-3-carboxylate to give ethyl 1-(3-fluoro-4-(5-(2-phenylpropan-2-yl)benzofuran-2-yl)benzyl)azetidine-3-carboxylate as a yellow foam. MS (ESI) m/z: Calculated: 471.2; Observed: 472 (M++1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07919519B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-4a7d4f6931954ec8ba286d4526a1f2e2 |
| Source note | uspto-grants-2011_04 |