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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2075219Generated: October 25, 2026

Methyl 1-(4-ethynyl-3-fluorobenzyl)azetidine-3-carboxylate → Methyl 1-((3-fluoro-4-(5-(phenylmethyl)furo[2,3-b]pyridin-2-yl)phenyl)methyl)-3-azetidinecarboxylate

https://huagongshe.com/reaction/2075219

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 1-(4-ethynyl-3-fluorobenzyl)azetidine-3-carboxylateHCID 25254788—
ReactantHCID 178517721HCID 178517721—
ProductMethyl 1-((3-fluoro-4-(5-(phenylmethyl)furo[2,3-b]pyridin-2-yl)phenyl)methyl)-3-azetidinecarboxylateHCID 58415398—

Reaction Steps

Synthesized according to Scheme B3 and general procedure G from 5-benzyl-3-iodopyridin-2-ol (0.400 g, 1.29 mmol) and methyl 1-(4-ethynyl-3-fluorobenzyl)azetidine-3-carboxylate (0.381 g, 1.54 mmol): light yellow solid. MS (ESI) m/z: Calculated: 430.2; Observed: 431.1 (M++1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07919519B2
Source datasetuspto-grants-2011_04
ORD IDord-d61352741e6c4c899e1a10f4369c8d82
Source noteuspto-grants-2011_04