HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 1-(4-ethynyl-3-fluorobenzyl)azetidine-3-carboxylate → Methyl 1-((3-fluoro-4-(5-(pyrimidin-2-ylmethyl)benzofuran-2-yl)phenyl)methyl)azetidine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 1-(4-ethynyl-3-fluorobenzyl)azetidine-3-carboxylate | HCID 25254788 | — |
| Reactant | 2-Iodo-4-(pyrimidin-2-ylmethyl)phenol | HCID 58415247 | — |
| Product | Methyl 1-((3-fluoro-4-(5-(pyrimidin-2-ylmethyl)benzofuran-2-yl)phenyl)methyl)azetidine-3-carboxylate | HCID 58415276 | — |
Reaction Steps
Synthesized according to Scheme B3 and general procedure G from 2-iodo-4-(pyrimidin-2-ylmethyl)phenol (0.230 g, 0.74 mmol) and methyl 1-(4-ethynyl-3-fluorobenzyl)azetidine-3-carboxylate (0.220 g, 0.89 mmol). MS (ESI) m/z: Calculated: 431.2; Observed: 432.5 (M++1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07919519B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-3797f8b35c6b45fc9d5eb5f5d2dc32fc |
| Source note | uspto-grants-2011_04 |