HCID 22062850, compound → HCID 58415397, compound

HRID 2075231Notes

Reaction equation

HRID 2075231 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[O:9])=[CH:4][C:3]=1I.[C:17]([C:19]1[CH:33]=[CH:32][C:22]([CH2:23][N:24]2[CH2:27][CH:26]([C:28]([O:30][CH3:31])=[O:29])[CH2:25]2)=[CH:21][C:20]=1[F:34])#[CH:18]>>[C:8]([C:5]1[CH:6]=[CH:7][C:2]2[O:1][C:17]([C:19]3[CH:33]=[CH:32][C:22]([CH2:23][N:24]4[CH2:27][CH:26]([C:28]([O:30][CH3:31])=[O:29])[CH2:25]4)=[CH:21][C:20]=3[F:34])=[CH:18][C:3]=2[CH:4]=1)(=[O:9])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 22062850HCID 22062850, compoundHCID 25254788Methyl 1-(4-ethynyl-3-fluorobenzyl)azetidine-3-carboxylate

Product 1

HCID 58415397HCID 58415397, compound

Procedure

Synthesized according to Scheme B3, Step 3 and general procedure G from (4-hydroxy-3-iodophenyl)(phenyl)methanone and methyl 1-(4-ethynyl-3-fluorobenzyl)azetidine-3-carboxylate: yellow-orange solid. MS (ESI) m/z: Calculated: 443.2; Observed: 444 (M++1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-84cc6444a0c5405e965460b5311cf582
Source dataset
uspto-grants-2011_04
Patent number
US07919519B2

Reaction notes

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