Methyl 1-(4-ethynyl-3-fluorobenzyl)azetidine-3-carboxylate → HCID 58415358, compound

Participants

Reaction Steps

Synthesized according to Scheme B3 and general procedure G from 6-benzyl-2-iodopyridin-3-ol (0.500 g, 1.61 mmol) and methyl 1-(4-ethynyl-3-fluorobenzyl)azetidine-3-carboxylate (0.477 g, 1.93 mmol). 1H NMR (300 MHz, CDCl3) δ ppm 7.93 (t, J=7.9 Hz, 1H), 7.65 (d, J=8.5 Hz, 1H), 7.37 (d, J=3.1 Hz, 1H), 7.10-7.33 (m, 7H), 7.04 (d, J=8.5 Hz, 1H), 4.27 (s, 2H), 3.72 (s, 3H), 3.65 (s, 2H), 3.48-3.60 (m, 2H), 3.30-3.40 (m, 3H). MS (ESI) m/z: Calculated; 430.2 Observed: 431.1 (M++1).

Provenance & Evidence