反应详情

温度

60 °C

To a slurry of S-2-amino-4-benzylphenyl dimethylcarbamothioate (1.43 g, 4.99 mmol) in 15 mL ethylene glycol was added potassium hydroxide (0.840 g, 15.0 mmol) (solid, finely crushed). The reaction was heated to 60° C. under nitrogen. 10 mL 2-BuOH was added as cosolvent and the resulting solution was heated for 2 h. The reaction was fitted with a water-cooled reflux condensor and heated to 90° C. for 3 h. The reaction was cooled, and concentrated in vacuo. The material was partitioned between Et2O and water. The organic layer was dried over sodium sulfate, filtered, and concentrated in vacuo to give an oil, which was purified by silica gel chromatography, ISCO, 0-30% EtOAc/hexanes to give 2-(2-(2-amino-4-benzylphenyl)disulfanyl)-5-benzylbenzenamine as a brown oil. MS (ESI) m/z: Calculated: 428.1; Observed: 429.0 (M++1).

1. customfinely crushed)
2. temperaturethe resulting solution was heated for 2 h
3. temperaturecooled
4. temperaturereflux condensor
5. temperatureheated to 90° C. for 3 h
6. temperatureThe reaction was cooled
7. concentrationconcentrated in vacuo
8. customThe material was partitioned between Et2O and water
9. dry with materialThe organic layer was dried over sodium sulfate
10. filtrationfiltered
11. concentrationconcentrated in vacuo
12. customto give an oil, which
13. customwas purified by silica gel chromatography, ISCO, 0-30% EtOAc/hexanes