Acetone → HCID 57991879, compound

Participants

Reaction Steps

Example 2 (5-(5-((S)-2-amino-3-(4-(trifluoromethyl)phenyl)propylamino)-1,3,4-thiadiazol-2-yl)indolin-2-one) (40 mg, 46 μmol) was dissolved in 1 mL of anhydrous acetone. To the resulting solution was added 2.0 mL of 2.0M ammonia in MeOH. The resulting mixture was stirred for one hour. After removing the solvent, the title compound was obtained as a white solid (20 mg, 48%). LCMS (API-ES) m/z (%): 474.1 (100%, M++H); 1H NMR (400 MHz, CD3OD) δ ppm 2.45 (s, 3H) 2.59 (s, 3H) 3.06-3.18 (m, 2H) 3.54-3.65 (m, 1H) 3.66-3.76 (m, 1H) 3.86-3.96 (m, 1H) 6.94 (d, J=8.22 Hz, 1H) 7.49-7.57 (m, 3H) 7.62-7.70 (m, 2H) 8.00 (s, 1H).

Provenance & Evidence