Hydrochloric Acid → 4-Chlorothieno[2,3-c]pyridine-2-carboxylic acid

Participants

Reaction Steps

Methyl 4-chlorothieno[2,3-c]pyridine-2-carboxylate (19.76 g) was dissolved in 100 mL THF and treated with 100 mL 2M LiOH at room temperature for 3 hours. The reaction mixture was acidified with concentrated HCl to pH=4. A white solid (17.93 g, y=97%) was obtained after filtration, washing with MeOH and air drying. LCMS (API-ES) m/z (%): 214.1 (100%, M++H); 1H NMR (300 MHz, CD3OD) δ ppm 8.35 (s, 1H) 8.71 (s, 1H) 9.54 (s, 1H).

Provenance & Evidence