Hydrochloric Acid → HCID 57991933, compound

Participants

Reaction Steps

To a solution of (2R,5S)-2-isopropyl-3,6-dimethoxy-5-((S)-methoxy(4-(trifluoromethyl)phenyl)methyl)-2,5-dihydropyrazine (3.40 g, 9.1 mmol) in THF (25 mL) and CH3CN (50 mL) was added 0.25 N hydrochloric acid (73 mL, 18 mmol) at room temperature. The mixture was stirred overnight and the solvent was removed in vacuo. The residue was neutralized with saturated NaHCO3 and extracted with ether. The organic layer was dried over Na2SO4 and concentrated in vacuo. The resulting residue was purified by silica gel chromatography (30%-50% EtOAc-hexane) to provide the product as a colorless oil (1.1 g, 43%). LCMS (API-ES) m/z (%): 278 (M+H).

Provenance & Evidence