HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → Ethyl 2-oxo-2,3-dihydrobenzo[d]oxazole-6-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | Benzoic acid, 4-amino-3-hydroxy-, methyl ester | HCID 7020619 | — |
| Product | Ethyl 2-oxo-2,3-dihydrobenzo[d]oxazole-6-carboxylate | HCID 15422978 | — |
Reaction Steps
Methyl 4-amino-3-hydroxybenzoate (1.23 g, 7.36 mmol) (commercially available from Pfaltz & Bauer Chemicals Catalog (Order Number A22677)) and 1,1′-carbonyldiimidazole (1.19 g, 7.36 mmol) in 20 mL THF were heated by microwave at 100° C. for 10 minutes. The reaction mixture was used directly for next step. LCMS (API-ES) m/z: 194 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07919504B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-4fb885a549b0401d84650fbea183dcfa |
| Source note | uspto-grants-2011_04 |