Hydrochloric Acid → HCID 58488311, compound

Participants

Reaction Steps

To a solution of (2S,5R)-2-((S)-(tert-butyldimethylsilyloxy)(4-(trifluoromethyl)phenyl)methyl)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine (3.1 g, 6.6 mmol) in THF (15 mL) and CH3CN (30 mL) was added 0.25 N hydrochloric acid (53 mL, 13 mmol) at room temperature. The mixture was stirred over the weekend and then concentrated in vacuo. The residue was neutralized with saturated NaHCO3 and extracted with EtOAc three times. The organic layer was dried over Na2SO4 and concentrated in vacuo. The residue was purified by chromatography on silica gel (0-25%-50% EtOAc-hexane) to provide the product as colorless oil (2.1 g, 84%). LCMS (API-ES) m/z: 378 (M+H+).

Provenance & Evidence