HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → N-(2-aminoethyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | HCID 67089624 | HCID 67089624 | — |
| Reactant | HCID 67090547 | HCID 67090547 | — |
| Product | N-(2-aminoethyl)acetamide | HCID 66082 | — |
| Product | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Product | 1-Hydroxybenzotriazole hydrate | HCID 2796029 | — |
Reaction Steps
In a similar manner to Example 5, Compound 38 (240 mg, 36%) was obtained using (E)-3-[2-(1H-indazol-3-yl)vinyl]benzoic acid (500 mg, 1.89 mmol) obtained in a similar manner to Step 6 of Example 1, N-acetylethylenediamine (290 mg, 3.82 mmol), 1-hydroxybenzotriazole monohydrate (332 mg, 2.46 mmol), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (510 mg, 2.66 mmol) and N-methylmorpholine (420 μL, 3.82 μmmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07919517B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-daa29b581d414a09b933c13972006e8b |
| Source note | uspto-grants-2011_04 |