2-Naphthalenecarboxylic acid, 1-hydroxy-, methyl ester → HCID 66701115, compound

HRID 2075508Notes

Reaction equation

HRID 2075508 reaction equation
COC(C1C=CC2C(=CC=CC=2)C=1O)=O.ClCC1C=CC(C(F)(F)F)=NC=1.[C:28]([C:30]([NH:33][C:34]([C:36]1[CH:45]=[CH:44][C:43]2[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=2)[C:37]=1[O:46][CH2:47][C:48]1[CH:49]=[N:50][C:51]([C:54]([F:57])([F:56])[F:55])=[CH:52][CH:53]=1)=[O:35])([CH3:32])[CH3:31])#[N:29].NC(C)(C)C#N>>[C:28]([C:30]([NH:33][C:34]([C:36]1[CH:45]=[CH:44][C:43]2[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=2)[C:37]=1[O:46][CH2:47][C:48]1[CH:49]=[N:50][C:51]([C:54]([F:55])([F:57])[F:56])=[CH:52][CH:53]=1)=[O:35])([CH3:32])[CH3:31])#[N:29]

Participants

4

Reactant 3

HCID 703582-Naphthalenecarboxylic acid, 1-hydroxy-, methyl esterHCID 27738105-(Chloromethyl)-2-(trifluoromethyl)pyridineHCID 66701337HCID 66701337, compound

Product 1

HCID 66701115HCID 66701115, compound

Procedure

In analogy to steps a) and b) of example 3 starting from 1-hydroxy-naphthalene-2-carboxylic acid methyl ester using 5-chloromethyl-2-trifluoromethyl-pyridine and performing the amidation reaction using 2-amino-2-methyl-propionitrile 1-(6-trifluoromethyl-pyridin-3-ylmethoxy)-naphthalene-2-carboxylic acid (cyano-dimethyl-methyl)-amide was obtained as a brown oil.

Workup

  1. customthe amidation reaction
  2. customwas obtained as a brown oil

Sources & evidence

ORD record
ord-79663c1aa1304fe299e326bffa868097
Source dataset
uspto-grants-2011_04
Patent number
US07919628B2

Reaction notes

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