HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 58370291, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | HCID 66701226 | HCID 66701226 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 58370291 | HCID 58370291 | 52% |
Reaction Steps
207 mg 2-({1-[(E)-2-(4-isopropyl-phenyl)-vinyl]-naphthalene-2-carbonyl}-amino)-2-methyl-propionic acid methyl ester were dissolved in 6 ml of MeOH and 2 ml of water was added. After addition of 114 mg of LiOH.H2O the reaction was stirred at room temperature for 14 h. Filtration of the crude mixture, RP-HPLC and freeze-drying gave 104 mg of 2-({1-[(E)-2-(4-isopropyl-phenyl)-vinyl]-naphthalene-2-carbonyl}-amino)-2-methyl-propionic acid (42%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07919628B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-246276a5558b4aa18069a787d1caf706 |
| Source note | uspto-grants-2011_04 |