HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aniline → HCID 3785006, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2,6-Dichloro-3-nitropyridine | HCID 85239 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 3785006 | HCID 3785006 | 74% |
Reaction Steps
A mixture of 2,6-dichloro-3-nitropyridine (772 mg, 4 mmol), aniline (364 μL, 4 mmol) and DIEA (838 μL, 24.8 mmol) in 10 mL THF was stirred at r.t. for 70 h. After removal of the solvent, the residue was dissolved in DCM, and subjected to silica gel column purification to give 735 mg (yield 74%) of the title compound. LC-MS: Calculated mass=249. Observed mass=250.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07919617B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-e07905d29825416aa51e8075db1a1fbe |
| Source note | uspto-grants-2011_04 |