HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluidine → 2,6-Bis(p-tolylamino)-3-nitro-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluidine | HCID 7813 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2,6-Dichloro-3-nitropyrimidine | HCID 18469972 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2,6-Bis(p-tolylamino)-3-nitro-pyrimidine | HCID 67091440 | 95% |
Reaction Conditions
| Temperature | 200 °C |
|---|
Reaction Steps
A mixture of 2,6-dichloro-3-nitropyrimidine (194 mg, 1 mmol), p-tolylamine (236 mg, 2.2 mmol) and DIEA (524 μL, 3 mmol) in 3 mL dioxane was stirred in microwave at 200° C. for 20 min. After removal of the solvent, the residue was dissolved in chloroform and subjected to silica gel column purification to give 319 mg (yield: 95%) title compound. Calculated mass=335. Observed mass=336.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07919617B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-c6d454b1d7754e899d31c898d4923bb3 |
| Source note | uspto-grants-2011_04 |