3-tert-Butylaniline → HCID 22311124, compound

HRID 2075603Notes

Reaction equation

HRID 2075603 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([CH:9]=[CH:10][CH:11]=1)[NH2:8])([CH3:4])([CH3:3])[CH3:2].[N-]=[C:13]=[O:14]>C(Cl)Cl>[C:1]([C:5]1[CH:11]=[CH:10][CH:9]=[C:7]([N:8]=[C:13]=[O:14])[CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 793343-tert-ButylanilineHCID 105034Isocyanate

Product 1

HCID 22311124HCID 22311124, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-t-Butyl-aniline (150 mg, 1 mmol) was converted to the isocyanate as described above and then dissolved in 4 mL DCM. Hydrazate (104 mg, 1 mmol) was added and the reaction was continued at rt overnight. Preparative LC-MS purification afforded 181 mg of the target compound as a white solid.

Workup

  1. additionHydrazate (104 mg, 1 mmol) was added
  2. customPreparative LC-MS purification

Sources & evidence

ORD record
ord-ea51902b0549433c84b4ea744dfd3234
Source dataset
uspto-grants-2011_04
Patent number
US07919617B2

Reaction notes

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