HCID 58687739, compound → HCID 21252464, compound

HRID 2075626Notes

Reaction equation

HRID 2075626 reaction equation
C([O:8][C:9](=[O:29])[CH2:10][O:11][CH2:12][CH2:13][O:14][CH2:15][CH2:16][O:17][CH2:18][CH2:19][O:20][CH2:21][CH2:22][O:23][CH2:24][CH2:25][N:26]=[N+]=[N-])C1C=CC=CC=1>CO.[Pd]>[NH2:26][CH2:25][CH2:24][O:23][CH2:22][CH2:21][O:20][CH2:19][CH2:18][O:17][CH2:16][CH2:15][O:14][CH2:13][CH2:12][O:11][CH2:10][C:9]([OH:29])=[O:8]

Participants

4

Reactant 1

HCID 58687739HCID 58687739, compound

Product 1

HCID 21252464HCID 21252464, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The Compound 6 obtained in Production Example 9 (1.94 g, 4.72 mmol) was dissolved in methanol (50 ml), 10% Pd—C (500 mg) was added, and catalytic hydrogenation was conducted at room temperature for 2.5 hours. The solid was removed by Celite filtration and washed with methanol, and the filtrate and the washings were combined and concentrated under reduced pressure to yield the desired [2-(2-{2-[2-(2-amino-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]acetic acid (Compound 7; 1.4 g, quantitative).

Workup

  1. customThe solid was removed by Celite filtration
  2. washwashed with methanol
  3. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-f574fac316ab424a9d9ede88ffc1ecad
Source dataset
uspto-grants-2011_04
Patent number
US07919653B2

Reaction notes

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