[2-(2-{2-[2-(2-{4-[2-(2-{2-[2-(2-Azido-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-phenoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]acetic acid tert-butyl ester → [2-(2-{2-[2-(2-{4-[2-(2-{2-[2-(2-Amino-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-phenoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]acetic acid tert-butyl ester

Participants

Reaction Steps

In a nitrogen atmosphere, to a suspension of palladium hydroxide (20% by weight; 18 mg) in methanol (1 ml), a solution of Compound 27 (190 mg, 0.323 mmol) in methanol (1.5 ml) was added; after the nitrogen atmosphere was replaced with a hydrogen atmosphere, stirring was conducted at room temperature for 1 hour. After a nitrogen atmosphere was restored, insoluble matter was separated by filtration on Celite and washed with methanol. Concentration under reduced pressure was conducted to yield a crude product of Compound 28.

Provenance & Evidence