Cesium carbonate → HCID 86613824, compound

Participants

Reaction Steps

2,4-Dibromo-7-bromomethyl-quinoline (1.0 g, 2.6 mmol), 4-(3-fluoro-5-hydroxy-phenyl)-tetrahydro-pyran-4-carboxylic acid methyl ester (1a, 670 mg, 2.6 mmol), and cesium carbonate (1.7 g, 5.3 mmol) were suspended in DMF (15 mL) and stirred overnight at room temperature. The mixture was diluted with EtOAc and saturated aqueous NH4Cl, and the aqueous layer was extracted with EtOAc. The combined organic layers were dried over MgSO4, filtered, and concentrated. The residue was purified by silica gel chromatography to give the desired product, 1b.

Provenance & Evidence