HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetone → 7-Iodo-2-methyl-imidazo[1,2-a]quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetone | HCID 6571 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 6-Iodoquinolin-2-amine | HCID 58907866 | — |
| Catalyst | Tetrabutylammonium Iodide | HCID 67553 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 7-Iodo-2-methyl-imidazo[1,2-a]quinoline | HCID 67091349 | — |
Reaction Steps
6-Iodo-quinolin-2-ylamine (270 mg, 1.0 mmol), chloroacetone (111 mg, 1.2 mmol), sodium bicarbonate (252 mg, 3.0 mmol), and catalytic tetrabutylammonium iodide were dissolved in 1,4-dioxane and water, and stirred at 80° C. overnight. The reaction was cooled to room temperature and concentrated, and the residue was purified by preparative HPLC to give the desired compound, 1m.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07919621B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-b8743c82f76c40b78afa318037795788 |
| Source note | uspto-grants-2011_04 |