HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2075665Generated: November 1, 2026
Chloroacetaldehyde → 4-[3-(5-Phenyl-imidazo[1,2-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-ol
https://huagongshe.com/reaction/2075665
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chloroacetaldehyde | HCID 33 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 4-[3-(2-Amino-4-phenyl-quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile | HCID 67091091 | — |
| Catalyst | Sodium Bicarbonate | HCID 516892 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-[3-(5-Phenyl-imidazo[1,2-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-ol | HCID 24875766 | — |
Reaction Steps
To 1t (78 mg, 0.18 mmol) in 1,4-dioxane (3 mL) and water (1 mL) was added chloroacetaldehyde (50 wt %, 0.04 mL, 0.27 mmol) and saturated aqueous NaHCO3 (2 drops), and the reaction was heated to 70° C. until no starting material was seen by tlc analysis. The mixture was concentrated and purified by preparative HPLC to give the desired product, 1u.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07919621B2 |
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| Source dataset | uspto-grants-2011_04 |
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| ORD ID | ord-9cedc9dd10ab4bbcbe56d69391f3d249 |
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| Source note | uspto-grants-2011_04 |
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