HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2075666Generated: October 30, 2026
Ethyl bromopyruvate → 8-Iodo-5-phenyl-imidazo[1,2-a]quinoline-2-carboxylic acid ethyl ester
https://huagongshe.com/reaction/2075666
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl bromopyruvate | HCID 66144 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 7-Iodo-4-phenyl-quinolin-2-ylamine | HCID 67091129 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 8-Iodo-5-phenyl-imidazo[1,2-a]quinoline-2-carboxylic acid ethyl ester | HCID 67090699 | — |
Reaction Steps
7-Iodo-4-phenyl-quinolin-2-ylamine (100 mg, 0.29 mmol), ethyl bromopyruvate (0.05 mL, 0.43 mmol), and sodium bicarbonate (22 mg, 0.58 mmol) were dissolved in EtOH (2 mL) and heated to 80° C. for 3 hours. The mixture was concentrated and purified by silica gel chromatography (30% EtOAc in hexanes) to give the desired product, 1v.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07919621B2 |
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| Source dataset | uspto-grants-2011_04 |
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| ORD ID | ord-bc4650ef960048d5aee8ceba48aeb397 |
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| Source note | uspto-grants-2011_04 |
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