HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 7-[3-(4-Methoxy-tetrahydro-pyran-4-yl)-phenylsulfanyl]-1,2-dihydro-imidazo[1,2-a]quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 58257754 | HCID 58257754 | — |
| Catalyst | Methyl iodide | HCID 6328 | — |
| Product | 7-[3-(4-Methoxy-tetrahydro-pyran-4-yl)-phenylsulfanyl]-1,2-dihydro-imidazo[1,2-a]quinoline | HCID 58926516 | — |
Reaction Steps
To a solution of 2c (42 mg, 0.11 mmol) in DMF was added sodium hydride (5 mg, 0.12 mmol). Iodomethane (one drop) was added, and the mixture was stirred at room temperature for 5 hours. The reaction was quenched with water, extracted with EtOAc, and purified by preparative HPLC to give the desired product, 2d.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07919621B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-e203a1947ade42488940c3a34bafb33f |
| Source note | uspto-grants-2011_04 |