Cesium carbonate → HCID 86613829, compound

Participants

Reaction Steps

7-Bromomethyl-2,4-dichloro-quinoline (1.4 g, 4.8 mmol), 4-(3-Fluoro-5-hydroxy-phenyl)-tetrahydro-pyran-4-carboxylic acid methyl ester (5a, 1.2 g, 4.8 mmol), and cesium carbonate (3.1 g, 9.6 mmol) were suspended in DMF (20 mL) and stirred overnight at room temperature. The mixture was diluted with EtOAc and saturated NH4Cl, and the aqueous layer was extracted with EtOAc. The combined organic layers were dried over MgSO4, filtered, and concentrated, and the residue was purified by silica gel chromatography (30% EtOAc in hexanes) to give the desired product, 5b.

Provenance & Evidence