Potassium Fluoride → HCID 67091001, compound

Participants

Reaction Conditions

Reaction Steps

5s (70 mg, 0.17 mmol), m-tolylboronic acid (34 mg, 0.25 mmol), Pd2dba3 (4 mg, 0.01 mmol), potassium fluoride (29 mg, 0.50 mmol), and 2-(di-tert-butylphosphino)biphenyl (5 mg, 0.02 mmol) were dissolved in THF (5 mL) and degassed with N2 for 5 minutes. The reaction was heated to 80° C. for 5 hours, then cooled to room temperature and concentrated. The residue was purified by preparative HPLC to give the desired product, 5t.

Provenance & Evidence