Acetone → HCID 67091169, compound

HRID 2075703Notes

Reaction equation

HRID 2075703 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:19]=[C:20]([C:22]2([O:28][CH3:29])[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)[CH:21]=1)[O:5][CH2:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[C:12]([NH:17][NH2:18])[CH:11]=[CH:10]2.[CH3:30][C:31]([CH3:33])=O>CCO>[F:1][C:2]1[CH:3]=[C:4]([CH:19]=[C:20]([C:22]2([O:28][CH3:29])[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)[CH:21]=1)[O:5][CH2:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]1[C:31]([CH3:33])([CH3:30])[NH:18][N:17]=[C:12]1[CH:11]=[CH:10]2

Participants

4

Reactant 2

HCID 180AcetoneHCID 67091055HCID 67091055, compound

Product 1

HCID 67091169HCID 67091169, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
75 °C

Procedure

{6-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenoxymethyl]-quinolin-2-yl}-hydrazine (36 mg, 0.09 mmol) was suspended in EtOH (2 mL). Acetone (0.01 mL, 0.18 mmol) was added, and the reaction was heated at 75° C. overnight. The mixture was concentrated and purified by silica gel chromatography to give the desired product, 6a.

Workup

  1. concentrationThe mixture was concentrated
  2. custompurified by silica gel chromatography

Sources & evidence

ORD record
ord-a3ea76337a234b09bba29e4a8aaa3edb
Source dataset
uspto-grants-2011_04
Patent number
US07919621B2

Reaction notes

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