Methyl iodide → HCID 67090942, compound

Participants

Reaction Conditions

Reaction Steps

7c (58 mg, 0.12 mmol) was dissolved in THF (1.2 μL) and cooled to 0° C. Potassium tert-butoxide (18 mg, 0.16 mmol) was added, followed by iodomethane (0.01 mL, 0.18 mmol), and the reaction was warmed to room temperature and stirred overnight. The reaction was diluted with EtOAc and water, and the aqueous layer was extracted with EtOAc. The combined organics were washed with brine, dried over MgSO4, filtered, and concentrated. The residue was purified by silica gel chromatography (20-100% EtOAc, followed by 10% MeOH in EtOAc) to give the desired product, 7d.

Provenance & Evidence