Trifluoroacetic acid → 7-(5-Dicyclopropylmethyl-thiazol-2-ylsulfanyl)-1-phenyl-[1,2,4]triazolo[4,3-a]quinoline

Participants

Reaction Steps

To 10g (23 mg, 0.05 mmol) in CH2Cl2 (3 mL) was added triethylsilane (0.04 mL, 0.24 mmol) and TFA (0.04 mL, 0.49 mmol) at 0° C. After 4 hours at room temperature, additional triethylsilane (0.02 mL, 0.12 mmol) and TFA (0.02 mL, 0.25 mmol) as added at 0° C., and the reaction was stirred for another 3 hours at room temperature. The reaction was washed with saturated aqueous NaHCO3, and the aqueous layer was extracted with EtOAc. The combined organic layers were dried over MgSO4, filtered, and concentrated. The crude material was purified by silica gel chromatography to give the desired product, 10h.

Provenance & Evidence