Benzophenone imine → HCID 58257768, compound

Participants

Reaction Conditions

Reaction Steps

10n (500 mg, 1.8 mmol), benzophenone imine (0.31 mL, 1.8 mmol), sodium tert-butoxide (265 mg, 2.8 mmol), BINAP (115 mg, 0.2 mmol), and Pd2dba3 (42 mg, 0.05 mmol) were dissolved in toluene (10 mL) and degassed for 10 minutes with N2. The reaction was then sealed and heated to 80° C. for 2 hours. After cooling to room temperature, the mixture was diluted with EtOAc and brine, and the aqueous layer was extracted with EtOAc. The combined organic layers were dried over MgSO4, filtered, and concentrated, and the residue was purified by silica gel chromatography (30% EtOAc in hexanes) to give the desired product, 10p.

Provenance & Evidence